quantitative immunoexpression of egfr in oral potentially malignant disorders: oral leukoplakia and oral submucous fibrosis

Quantitative Immunoexpression of EGFR in Oral Potentially Malignant Disorders: Oral Leukoplakia and Oral Submucous Fibrosis

Background and aims. Many oral squamous cell carcinomas develop from potentially malignant disorders (PMDs)which include a variety of lesions and conditions characterized by an increased risk for malignant transformation. Thisstudy evaluated the quantitative expression of EGFR in normal oral mucosa, oral leukoplakia and oral submucous fibrosis to predict the malignant risk in compliance with th...

Oral Submucous Fibrosis: A Chronic Deliberating Disease of Oral Cavity

Oral submucous fibrosis is chronic progressive condition of oral cavity. The condition is well recognized for its malignant potential. Usually the disease initiates with redness, blistering, and ulceration inside the mouth. It is characterized by progressive fibrosis of submucosal tissue. The pathogenesis of oral submucous fibrosis is not well understood. Betelquid chewing is the major etiologi...

Oral Cancer and Oral Potentially Malignant Disorders

Metallothionein immunoexpression in oral leukoplakia.

OBJECTIVES to report the immunoexpression of metallothionein in oral leukoplakia and to correlate with histological grade and clinical localization. Leukoplakia is the most common potentially malignant lesion of the oral cavity. As the histological study of oral leukoplakia can not predict precisely the malignant transformation of this lesion, and metallothionein is a protein that has been asso...

Proinflammatory cytokine levels in oral lichen planus, oral leukoplakia, and oral submucous fibrosis

OBJECTIVES The objective of this study was to identify salivary and serum concentrations of interleukin (IL)-8, IL-6, and tumor necrosis factor alpha (TNF-α) in patients with oral lichen planus, oral leukoplakia, oral submucous fibrosis, and healthy controls. MATERIALS AND METHODS Patients selected included 54 oral lichen planus (41 to 65 years), 50 oral leukoplakia (42 to 65 years), 51 oral ...

Malignant transformation of oral submucous fibrosis

Several studies have demonstrated an independent association of deleterious oral habits such as smoking, betel quid chewing, and chewing tobacco with the occurrence of oral cancer. The potentially malignant conditions such as oral submucous fibrosis (OSF), leukoplakia, erythroplakia associated with smoking, and smokeless tobacco, have a greater prevalence in our country. OSF has high cancer tur...